The increasing complexity and interconnectedness of global supply chains have exposed organizations to unprecedented levels of risk and uncertainty. The COVID-19 pandemic, natural disasters, and geopolitical tensions have highlighted the critical importance of supply chain resilience in maintaining business continuity. This article examines how digital transformation initiatives, including automation, artificial intelligence, blockchain technology, and advanced analytics, are revolutionizing supply chain management in the United States. Through comprehensive analysis of industry data, case studies, and emerging trends, this research demonstrates that organizations leveraging digital tools achieve significantly higher levels of supply chain resilience, operational efficiency, and competitive advantage. The findings suggest that strategic digital transformation investments are not merely technological upgrades but fundamental reimagining of supply chain operations that enable rapid adaptation to disruptions and long-term sustainability.