The 21st century education system prioritizes students to have critical, creative, collaborative thinking skills and communication skills, including higher-order thinking skills. This study aims to develop online teaching materials for HOTS-based integrated General Chemistry courses using the ADDIE model to improve students' higher order thinking skills. This development research resulted in HOTS-based integrated online teaching materials that were feasible and effective in improving students' higher order thinking skills. Through the HOTS-based media integrated online teaching materials produced, students are required and trained to be able to think critically, creatively, analytically towards existing information and data and have the ability to solve problems.