The aerospace and defense industries rely on high-precision engineering, where even microscopic contaminants can compromise mission-critical components. Cleanroom-driven manufacturing has become a fundamental enabler of advanced aerospace systems, military hardware, and defense technologies, ensuring optimal performance, reliability, and compliance with stringent quality control standards. As global threats evolve and technological superiority becomes paramount, cleanroom-controlled production environments play a crucial role in enhancing military readiness, aircraft durability, and space exploration capabilities. From a broader perspective, the integration of cleanroom technologies into aerospace and defense manufacturing has driven advancements in aircraft assembly, avionics production, missile guidance systems, and space vehicle development. By maintaining strict environmental controls over temperature, humidity, and particulate contamination, cleanrooms enable the fabrication of high-performance materials, precision components, and secure electronics essential for national security. The adoption of ISO and AS9100-certified cleanroom standards further strengthens manufacturing resilience, defect prevention, and regulatory compliance, ensuring that U.S. aerospace and defense capabilities remain globally competitive. At a more granular level, the economic implications of cleanroom-driven aerospace manufacturing are substantial. By fostering domestic production and technological sovereignty, cleanroom infrastructure reduces supply chain vulnerabilities, supports defense contractor expansion, and creates high-skilled employment opportunities. Moreover, cleanroom innovations—such as modular cleanroom designs, energy-efficient HVAC systems, and automated contamination control technologies—optimize cost efficiency and sustainability in aerospace production. Looking ahead, continued investments in cleanroom R&D, digital twin simulations, and AI-enhanced contamination monitoring will be pivotal in shaping the next generation of aerospace defense systems, hypersonic weapons, and space exploration technologies, reinforcing the United States’ strategic advantage and economic growth.