Sustainable supply chain design has emerged as a strategic imperative as organizations confront escalating environmental pressures, social accountability expectations, and increasingly complex regulatory regimes. At a broad level, sustainability-oriented supply chains seek to balance economic performance with environmental stewardship and social responsibility across interconnected global networks. This holistic perspective emphasizes systems thinking, long-term value creation, and cross-functional integration rather than isolated efficiency gains. Within this context, ethical sourcing, logistics optimization, emissions mitigation, circular economy practices, and regulatory compliance define core pillars of modern sustainable supply chain architecture. From an ethical standpoint, sustainable supply chain design prioritizes responsible sourcing practices that safeguard labor rights, promote supplier transparency, and mitigate social and environmental risks upstream. Concurrently, logistics efficiency plays a central role by reducing waste, minimizing transit distances, and leveraging digital technologies to enhance visibility, coordination, and resilience. These improvements contribute directly to emissions reduction objectives through modal shifts, energy-efficient transportation, optimized inventory strategies, and data-driven network design. Narrowing further, circularity has become a defining mechanism for embedding sustainability into supply chains. By integrating product life-cycle thinking, reverse logistics, remanufacturing, and material recovery processes, organizations can decouple value creation from resource depletion while improving cost efficiency and supply security. However, the effectiveness of these strategies is increasingly shaped by regulatory compliance requirements. Environmental reporting mandates, carbon disclosure frameworks, and due diligence regulations compel firms to formalize sustainability practices, standardize metrics, and align supply chain decisions with policy expectations. Taken together, sustainable supply chain design represents a multidimensional framework in which ethical sourcing, logistics efficiency, emissions reduction, circularity, and regulatory compliance function as interdependent design variables. Integrating these dimensions enables organizations to achieve excellence.