The rapid digital transformation in healthcare has accelerated the evolution of smart hospital infrastructure, fundamentally reshaping the delivery, coordination, and monitoring of patient care. As healthcare systems increasingly integrate technologies such as Internet of Medical Things (IoMT), artificial intelligence (AI), robotic process automation (RPA), electronic health records (EHRs), and smart sensors, nurse leaders are expected to play a pivotal role in guiding the ethical and strategic implementation of these tools. From an institutional perspective, smart hospital infrastructure refers to interconnected systems designed to improve operational efficiency, real-time clinical decision-making, and patient outcomes. However, the successful deployment of these technologies is not solely dependent on hardware or software but also on informed leadership that bridges clinical insight with digital innovation. This abstract explores the evolving landscape of smart hospitals and emphasizes what nurse leaders must know to remain relevant and effective in tech-enhanced healthcare environments. It begins by examining broad trends such as AI-driven diagnostics, predictive analytics for workforce optimization, and digital twin modeling for intensive care units. It then narrows its focus to implications for nurse managers—particularly in fostering tech-literate teams, leading EHR optimization efforts, navigating cybersecurity risks, and promoting equitable digital health access. Emphasis is placed on the need for continuous professional development, collaborative interdepartmental leadership, and the alignment of emerging technologies with patient-centered care models. With nurse leaders positioned as frontline implementers of innovation, understanding smart infrastructure is no longer optional but essential. This paper concludes by calling for enhanced training, policy reform, and the inclusion of nurses in strategic technology planning to ensure a human-centered transition toward the hospital of the future.