Cybersecurity incidents have become one of the most significant threats to national security, economic stability, and organizational integrity in the United States. The increasing frequency, sophistication, and scale of cyberattacks, including ransomware, data breaches, and Distributed Denial of Service (DDoS) attacks, have prompted both public and private sectors to bolster their cybersecurity frameworks. Effective cybersecurity incident response and crisis management are critical in mitigating the impact of these incidents, minimizing damage, and ensuring continuity of operations. In response to evolving cyber threats, the U.S. has developed comprehensive cybersecurity strategies that emphasize proactive threat intelligence, rapid incident detection, and coordinated response efforts. The National Institute of Standards and Technology (NIST) and the Cybersecurity and Infrastructure Security Agency (CISA) have outlined key frameworks and guidelines that help organizations prepare for and manage cyber incidents. These frameworks focus on establishing clear protocols for identifying, containing, and recovering from attacks while maintaining communication with stakeholders. This paper delves into the principles of cybersecurity incident response, examining the roles of various stakeholders, including government agencies, private organizations, and law enforcement, in crisis management. It highlights the importance of coordination, communication, and continuous monitoring during and after an incident. The paper also discusses the challenges faced by organizations in responding to cyberattacks, such as resource limitations, regulatory complexities, and the evolving nature of cyber threats. As cyber threats continue to grow in complexity, the development of resilient incident response and crisis management plans will be essential in safeguarding critical infrastructure and sensitive data across the U.S.