Wildfires, residential fires, and industrial blazes collectively pose a persistent threat to public safety, infrastructure, and economic stability in the United States. The absence of a harmonized and strictly enforced national fire safety compliance program leads to preventable loss of life, property damage, insurance volatility, and escalating federal disaster relief costs. While federal and local fire codes exist, significant disparities in enforcement, infrastructure resilience, and community risk awareness result in uneven protection across regions. This study seeks to quantify the risk mitigation and economic savings potential of implementing a comprehensive fire safety compliance program at the national scale. Drawing from actuarial loss models, fire department incident datasets, and economic simulations, we evaluate the cost-benefit implications of widespread compliance with best-in-class fire prevention measures—including building code updates, early warning systems, suppression technologies, and public education initiatives. Scenario modeling captures direct cost savings such as reduced structural losses and healthcare expenditures, alongside indirect gains including lowered insurance premiums, increased workforce productivity, and reduced demand for federal disaster aid. Results show that for every dollar invested in a robust fire safety compliance program, the U.S. could save between $4 and $7 in avoided losses and emergency expenditures. This research offers policymakers, insurers, and municipal planners a quantitative framework to assess fire safety strategies, prioritize resource allocation, and justify regulatory harmonization. Importantly, the study underscores that fire resilience is not only a safety imperative but an economically prudent national strategy—one that yields measurable financial returns while protecting lives and ecosystems from increasingly frequent and severe fire events.