Model Driven Architecture and Cloud computing are among the most important paradigms in software service engineering now a days. As cloud computing continues to gain more activities, more issues and challenges for many systems with its dynamic usage are introduced. Model Driven Architecture (MDA) approach for development and maintenance becomes an evident choice for ensuring software solutions that are robust, flexible and agile for developing applications. This paper aims to survey and analyze the research issues and challenges that have been emerging in cloud computing applications with a focus on using Model Driven architecture (MDA) development. We discuss the open research issues and highlight future research problems.