The techniques and tests are tools used to define how measure the goodness of ontology or its resources. The similarity between biomedical classes/concepts is an important task for the biomedical information extraction and knowledge discovery. However, most of the semantic similarity techniques can be adopted to be used in the biomedical domain (UMLS). Many experiments have been conducted to check the applicability of these measures. In this paper, we investigate to measure semantic similarity between two terms within single ontology or multiple ontologies in ICD-10 “V1.0” as primary source, and compare my results to human experts score by correlation coefficient.