In order to avoid the problem that single-domain spectral whitening cannot improve the time-frequency accuracy of seismic signals at the same time, this paper proposes a time-frequency domain spectral whitening based on synchrosqueezing generalized S transform(SSGST). First, the SSGST is used to perform time-frequency analysis on the seismic signal to obtain the time-frequency spectrum of the seismic signal. Then the whitening filter is used to perform spectral whitening on the time-frequency spectrum to obtain a seismic signal with higher time-frequency resolution. The verification of synthetic seismic signals and actual seismic signals proves that spectral whitening based on SSGST can simultaneously improve the time-frequency resolution of seismic signals, make the stratum information clearer, and have great significance for high-resolution processing of seismic signals.