Oral health has long been siloed from systemic disease management, despite robust evidence linking periodontal conditions to a wide range of chronic, immune, and inflammatory diseases such as diabetes, cardiovascular disorders, and rheumatoid arthritis. This paper proposes a comprehensive interdisciplinary framework for integrating oral health into national immune and inflammatory disease control programs. Starting from a global health perspective, the study outlines the burden of oral-systemic interactions and the consequences of neglecting dental care in public health strategies. As chronic inflammation and immune dysregulation underpin a multitude of systemic diseases, early detection and management of oral inflammation present a significant opportunity to enhance national disease prevention efforts. Drawing from epidemiological evidence, implementation science, and comparative health policy models, the paper presents a systems-based approach that aligns dental care with chronic disease surveillance, prevention, and care delivery. It advocates for the incorporation of oral health screenings in primary care settings, the development of integrated electronic health records linking dental and medical data, and the training of allied health professionals in oral-systemic care principles. Furthermore, the paper highlights successful models from Scandinavian, Canadian, and select sub-Saharan African health systems that demonstrate scalable pathways for interdisciplinary collaboration. The proposed framework emphasizes policy reforms to facilitate reimbursement structures, interdisciplinary referral systems, and health promotion campaigns targeting both professionals and the public. Ultimately, this research calls for the institutionalization of oral health within national public health agendas—particularly those addressing immune and inflammatory diseases—to achieve holistic, equitable, and sustainable health outcomes across populations.