This study aims to develop ICARE-based interactive learning media with the digestive system in humans as media content, which is used as a learning medium in the classroom as well as for students' independent learning, especially in class VIII SMP Muhammadiyah 16 Lubuk Pakam. The development of interactive learning media based on ICARE was obtained through observations from educators and students who stated that they needed learning media. Research development using the 4D method by Thiagarajan Has defined, designed, developed, and disseminated stages. The development process involves input from material experts, media experts, and instructional experts, as well as an acceptability test from students. The results showed that: (1) ICARE-based interactive learning media obtained a score of 4.42 for material experts, 4.69 for media experts, and 4.69 for instructional experts. In the field trial of interactive learning media, it obtained a mean value of 4.08 (high acceptability). Guidance and information aspects 4.07 (high), media material aspects 4.13 (high), evaluation aspects 4.10 (high), design aspects and media facilities 4.03 (high), and pedagogical aspects 4.09 (high), each of which indicates that the product being developed is very worth it. (2) The results of implementing ICARE-based interactive learning media were tested using the N-Gain Score to see the effectiveness of using media on learning outcomes. Research results show a 0.6 (moderate effectiveness). The conclusions of the ICARE-based interactive learning media research are feasible to use and effectively improve learning outcomes.