This research and development aims to produce PBL-based Informatics E-LKPD learning media to improve students' computational thinking skills. This type of research is development research using the 4D development model, namely: (1) define, (2) design, (3) develop, and (4) disseminate. The results of the study show: (1) Material expert validation tests show that the developed medium is very feasible, with an average score of 84%. (2) Instructional Design Expert validation test with very appropriate criteria and an average score of 87% (3) Media Expert validation test in the very proper category with an average score of 83%. (4) Individual trials with very good criteria and an average score of 90% (5) The criterion small group trial was very good, with an average score of 87%. and (6) Field trials with very good criteria and an average score of 89%. The practicality test by the teacher is very good, with an average score of 88%, while the results of the practicality test on students, with an average score of 90%, are in the very good category. The results of the experiment using PBL-based Informatics E-LKPD in the experimental class averaged 86 learning outcomes, while students who were taught without using PBL-based Informatics E-LKPD had an average score of 70. Hypothesis testing using the Independent t-test obtained a sig. (2-tailed) of 0.000, where the result is <0.05, shows a significant difference between classes taught using PBL-based Informatics E-LKPD and classes without using PBL-based Informatics E-LKPD. Therefore, the use of PBL-based informatics and E-LKPD in effective learning to improve students' computational thinking skills.