: ERP systems selection, adoption and implementation are a complex, lengthy and costly process which tends to face serious failure. Higher Education Institutions are rapidly adopting and implementing these systems despite some implementation failures that have been reported elsewhere. Thus, it is essential to perform post-implementation assessment of these systems to evaluate how much they have succeeded or failed in achieving their predetermined objectives. The purpose of this paper is to evaluate the effectiveness of topaz ERP systems in higher education institutions using a system integrative approach. Using a mixed-method research, data for quantitative and qualitative were collected and analyzed using partial least square – structural equation modeling (PLS-SEM) and inductive thematic analysis. The findings of the study revealed that financial perspective, customer/stakeholder perspective, and system quality perspective have significant influence or positive association with the effectiveness of topaz ERP systems evaluation in the Ghanaian higher education. The findings again, revealed that internal business process and learning and growth perspectives have no significant influence with the effectiveness of topaz ERP systems in Ghanaian context. Studies about the evaluation of ERP systems effectiveness in the Ghanaian higher education are rare. Available studies in Ghana have focused on the implementation issues and use only.